Jaeeon Lee

I am a postdoc in Nao Uchida's Lab at the MCB dept. I obtained my Ph.D at Harvard under Bernardo Sabatini in 2021, and was a recipeint of Harold M. Weintraub Graduate Student Award.

I am broadly interested in how the brain stores and updates value to guide optimal decisions. Currently, I'm exploring how mice learn strucutral knoweldge about the environment to do value inference.

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Research

Work during my Ph.D in Sabatini lab

Striatal indirect pathway mediates exploration via collicular competition

Jaeeon Lee*

, Bernardo Sabatini
Nature (2021) ,

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We dissected the functional impact of stimulating the striatal D2 indirect pathway, on behavior and neural dynamics in a downstream region (colliculus). We show that D2 pathway can both suppress and trigger movement on the contra/ipsi side respectively. This can be explained by paradoxical excitaiton of contralateral SC. We propose a general circuit mechanism for exploration mediated by basal ganglia-collicular circuit.

Anatomically segregated basal ganglia pathways allow parallel behavioral modulation

Jaeeon Lee*

, Wengang Wang, Bernardo Sabatini
Nature Neuroscience (2020)

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We show topographical loops starting from striatum to Pf, VM and SC in the mouse brain. Segregated pathways in medial vs ventrolateral striatum modulate turning/licking behavior respectively, confirming parallel organization of BG output pathways.

Depth-resolved fiber photometry with a single tapered optical fiber implant

Filippo Pisano*, Marco Pisanello*, Suk Joon Lee,

Jaeeon Lee

, et al
Nature Methods (2019)

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We show the application of tapered fibers in depth-selevtive photometry. We simultaenously recorded dopamine signals in dorsal/ventral striatum in the same mouse and show signals can diverge at specficic behavioral events.




Design and source code from Jon Barron's website